Weeden paired with Brian Mikkelson (Mequon, Wis.) to defeat Adrien Bailly and Chris Damion, 8-4, at No. 1 doubles, before fighting past Antonio Pena, 3-6, 6-3, 6-4, at No. 1 singles.
The Pride took a pair of victories at Nos. 2 and 3 doubles to take the doubles point. Quinnipiac won three of the first four singles flights to take a 3-2 lead in the match. In addition to Weeden's win, James Kwei (Dedham, Mass.) defeated Chris Damion, 6-0, 6-3, at No. 2 singles and Alex Lazerowich (Stratham, N.H.) defeated Matt Gemmell, 7-6 (7-4), 6-4, at No. 4.
But Hofstra took wins at Nos. 5 and 6 singles to earn the match victory.
The Bobcats return to action Saturday, when they welcome Northeast Conference foe Bryant to Hamden. First serve is scheduled for 1 p.m.